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Amelubant

Cat. No. M29955

All AbMole products are for research use only, cannot be used for human consumption.

Amelubant Structure
Synonym:

BIIL 284

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Quality Control & Documentation
Biological Activity

Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity.

Chemical Information
Molecular Weight 538.63
Formula C33H34N2O5
CAS Number 346735-24-8
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Daniel F J Ketelhuth, et al. Prostaglandins Other Lipid Mediat. The leukotriene B4 receptor (BLT) antagonist BIIL284 decreases atherosclerosis in ApoE-/- mice

[2] Claudia S Bitencourt, et al. J Cell Mol Med. Cooperative role of endogenous leucotrienes and platelet-activating factor in ischaemia-reperfusion-mediated tissue injury

[3] Gerd Döring, et al. J Cyst Fibros. BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs

[4] Sabina Schmitt-Grohé, et al. Paediatr Drugs. Leukotriene receptor antagonists in children with cystic fibrosis lung disease : anti-inflammatory and clinical effects

[5] M Bayés, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials

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Keywords: Amelubant, BIIL 284 supplier, Leukotriene Receptor, inhibitors, activators

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