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1A-116

Cat. No. M14051

All AbMole products are for research use only, cannot be used for human consumption.

1A-116 Structure

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Quality Control & Documentation
Biological Activity

1A-116 is a Rac1 inhibitor, with antitumoral and antimetastatic effects in several types of cancer, such as breast cancer. 1A-116 prevents Rac1-regulated processes involved in the primary tumorigenesis and metastastic processes .

Chemical Information
Molecular Weight 307.31
CAS Number 1430208-73-3
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Laura Luca Trebucq, et al. Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma

[2] Nazareno Gonzlez, et al. Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity

[3] Maia Cabrera, et al. Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines

[4] N Gonzalez, et al. Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells

[5] Iakov N Rudenko, et al. Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

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Keywords: 1A-116 supplier, Ras, inhibitors, activators

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