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1-BCP

Cat. No. M6321
1-BCP Structure
Synonym:

Piperonylic acid piperidide

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10mg USD 500  USD500 Custom Synthesis
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Quality Control & Documentation
Biological Activity

1-BCP (Piperonylic acid piperidide) is a a centrally active selective potentiator of AMPA-mediated responses. 1-BCP facilitates memory retention in rats.

Chemical Information
Molecular Weight 233.27
Formula C13H15NO3
CAS Number 34023-62-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A Arai, et al. Brain Res. A centrally active d rvg that modulates AMPA receptor gated currents

[2] M A Desai, et al. Neuropharmacology. 1-BCP, a memory-enhancing agent, selectively potentiates AMPA-induced [3H]norepinephrine release in rat hippocampal slices

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Keywords: 1-BCP, Piperonylic acid piperidide supplier, GluR, inhibitors, activators


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