Catalog

SGLT Sodium-glucose transport proteins

Inhibitors

Cat.No.	Name	Information
M9738	LX2761	LX2761 is a locally acting SGLT1 and SGLT2 inhibitor in vitro with IC50 values of 2.2 nM and 2.7 nM for hSGLT1 and hSGLT2, respectively.
M8956	Canagliflozin hemihydrate	Canagliflozin hemihydrate (JNJ-28431754; TA 7284) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM.
M5551	Dapagliflozin ((2S)-1,2-propanediol, hydrate)	Dapagliflozin(BMS512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) is in development for the treatment of type 2 diabetes mellitus (T2DM).
M5249	LX-4211	LX-4211 is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively.
M4607	Phloretin	Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
M4606	Phloridzin	Phloridzin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively.
M2667	Empagliflozin	Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6.
M2002	Canagliflozin	Canagliflozin is a potent, selective sodium glucose co-transporter 2 inhibitor.
M1937	Dapagliflozin	Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2).