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SGLT Sodium-glucose transport proteins

Cat.No.  Name Information
M1937 Dapagliflozin Dapagliflozin (BMS-512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2).
M30450 Mizagliflozin Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic agent that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation.
M28119 Licogliflozin Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor.
M21456 Enavogliflozin Enavogliflozin (DPW-16001), an antidiabetic compound, is a first class selective sodium-glucose cotransporter-2 (SGLT-2) inhibitor with oral activity.
M20844 Bexagliflozin (EGT1442) Bexagliflozin (EGT1442, EGT-0001442, THR-1442) is a potent and selective SGLT2 inhibitor with an IC50 of 2 nM.
M10441 Tofogliflozin (hydrate) Tofogliflozin (CSG-452) hydrate is a potent and highly specific sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 value of 2.9 nM.
M8956 Canagliflozin hemihydrate Canagliflozin hemihydrate (JNJ-28431754; TA 7284) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM.
M6272 Ertugliflozin Ertugliflozin (MK-8835, PF-04971729) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).
M6200 Ipragliflozin L-Proline Ipragliflozin is a selective sodium glucose cotransporter 2 (SGLT2) inhibitor that increases urinary glucose excretion by inhibiting renal glucose reabsorption and thereby causes a subsequent antihyper-glycemic effect.
M5551 Dapagliflozin ((2S)-1,2-propanediol, hydrate) Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate.
M5254 Ipragliflozin Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively.
M5249 LX-4211 LX-4211 is an orally active, first-in-class dual SGLT1/2 inhibitor with IC50s of 36 nM and 1.8 nM, respectively, and is used in studies related to type 1 diabetes and heart failure.
M4607 Phloretin Phloretin (NSC 407292; RJC 02792) is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2).
M4606 Phloridzin Phloridzin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively.
M2667 Empagliflozin Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6.
M2002 Canagliflozin Canagliflozin is a potent, selective sodium glucose co-transporter 2 inhibitor.
M31405 Tianagliflozin Tianagliflozin is an SGLT2 inhibitor that may be used in studies related to type 2 diabetes.
M31404 JTT-662 JTT-662 is an SGLT1 inhibitor that can be used in studies related to type 2 diabetes.
M31403 JP-2266 JP-2266 is a dual SGLT1/2 inhibitor that can be used in studies related to diabetes.
M30847 Tofogliflozin Tofogliflozin(CSG-452) is a potent and highly specific sodium/glucose cotransporter 2(SGLT2) inhibitor with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2.

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