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Bexagliflozin (EGT1442)

Cat. No. M20844
Bexagliflozin (EGT1442) Structure
Synonym:

EGT-0001442, THR-1442

Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 210  USD210 In stock
25mg USD 435  USD435 In stock
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Quality Control & Documentation
Biological Activity

Bexagliflozin (EGT1442, EGT-0001442, THR-1442) is a potent and selective SGLT2 inhibitor with an IC50 of 2 nM.

Chemical Information
Molecular Weight 464.94
Formula C24H29ClO7
CAS Number 1118567-05-7
Solubility (25°C) DMSO 90 mg/mL
Water 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wenbin Zhang, et al. Pharmacol Res. EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats

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Keywords: Bexagliflozin (EGT1442), EGT-0001442, THR-1442 supplier, SGLT, inhibitors, activators

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