| Cat.No. | Name | Information |
|---|---|---|
| M66397 | Recombinant Mouse Siglec-15 Protein (HEK293, C-6His) | Siglec-15 is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. |
| M66374 | Recombinant Mouse IL-1RA Protein (E. coli) | IL-1RA is a member of the interleukin 1 cytokine family. IL-1RA inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. |
| M66302 | Recombinant Human CSF1R Protein (HEK293, C-6His) | CSF1R is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. |
| M66300 | Recombinant Human LDLR Protein (HEK293, C-6His) | Low-Density Lipoprotein Receptor (LDLR) is a transmembrane glycoprotein that plays a critical role in cholesterol homeostasis. LDLR mediates blood cholesterol level by interacting with lipoprotein particles like LDL and VLDL. |
| M66013 | Recombinant Human DLL4 Protein (HEK293, C-Fc) | Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. DLL4 is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch 1 and Notch 4. Interactions of Notch receptors with their ligands result in reciprocal regulated intramembrane proteolysis. |
| M59150 | Recombinant Human ER alpha (E. coli, N-6His) | Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. |
| M59114 | Recombinant Human CXCR4 (HEK293, N-Fc) | CXCR4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 plays a role in both physiological and pathological conditions and it represents a crucial target in drug development. |
| M40857 | Recombinant Human SIGLEC-7 Protein (HEK293, His Tag) | Recombinant Human Sialic Acid-binding Ig-like Lectin 7 expressed the target gene encoding the Human SIGLEC7 (Q9Y286-1) (Met1-Leu353) was expressed with a polyhistidine tag at the C-terminus. The recombinant Human SIGLEC7 consists of 346 amino acids and predicts a molecular mass of 38.4 kDa. |
| M40855 | Recombinant Human Siglec-7 Protein (HEK293, C-6His) | Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. |
| M40853 | Recombinant Human SIGLEC-10 Protein (HEK293, mFc Tag) | The recombinant human SIGLEC-10 comprises 763 amino acids and has a calculated molecular mass of 84.60 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Thr546) was expressed with the Fc region of mouse IgG2a at the C-terminus. |
| M40852 | Recombinant Human SIGLEC-10 Protein (HEK293, His Tag) | The recombinant human SIGLEC-10 consists of 540 amino acids and predicts a molecular mass of 59.5 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Asn550) was expressed with a polyhistidine tag at the C-terminus. |
| M40845 | Recombinant Human Siglec-6 Protein (HEK293, C-Fc) | Siglec-6, also known as CD327, mediates sialic-acid dependent binding to cells. Siglec-6 binds to alpha-2,6-linked sialic acid. |
| M40843 | Recombinant Human Siglec-9 Protein (HEK293, C-Fc) | Sialic acid-binding Ig-like lectin 9(Siglec 9) is expressed by peripheral blood leukocytes, and found in liver, fetal liver, bone marrow, placenta, spleen and so on. It is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It also binds to alpha-2,3- or alpha-2,6-linked sialic acid. |
| M40842 | Recombinant Human Siglec-15 Protein (HEK293, C-mFc) | Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
| M40841 | Recombinant Human Siglec-15 Protein (HEK293, C-Fc) | Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
| M40844 | Recombinant Human Siglec-10 Protein (HEK293, C-Fc) | Siglec-10 binds sialated proteins and lipids in alpha 2,3 or alpha 2,6 linkage and shows a preference for GT1b gangliosides. This binding can be modulated by cis interactions of Siglec-10 with sialated molecules expressed on the same cell. |
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