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Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity.
Recombinant Human Sialic Acid-binding Ig-like Lectin 15 expressed the target gene encoding Phe20-Thr263 with a human IgG1 Fc tag at the C-terminus.
Loaded Human Siglec-15-Fc on AHC Biosensor, can bind Anti-Human Siglec15 mAb-mFc with an affinity constant of 0.13 nM as determined in BLI assay.
Accession: Q6ZMC9
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 50-80 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of PBS, 150mM NaCl, 0.3% Chaps, 5% Trehalose, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
[1] Saba Shafi et al. Lab Invest. Development of an immunohistochemical assay for Siglec-15
| Related Receptor Proteins Products |
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| Recombinant Human SIGLEC-7 Protein (HEK293, His Tag)
Recombinant Human Sialic Acid-binding Ig-like Lectin 7 expressed the target gene encoding the Human SIGLEC7 (Q9Y286-1) (Met1-Leu353) was expressed with a polyhistidine tag at the C-terminus. The recombinant Human SIGLEC7 consists of 346 amino acids and predicts a molecular mass of 38.4 kDa. |
| Recombinant Human Siglec-7 Protein (HEK293, C-6His)
Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. |
| Recombinant Human SIGLEC-10 Protein (HEK293, mFc Tag)
The recombinant human SIGLEC-10 comprises 763 amino acids and has a calculated molecular mass of 84.60 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Thr546) was expressed with the Fc region of mouse IgG2a at the C-terminus. |
| Recombinant Human SIGLEC-10 Protein (HEK293, His Tag)
The recombinant human SIGLEC-10 consists of 540 amino acids and predicts a molecular mass of 59.5 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Asn550) was expressed with a polyhistidine tag at the C-terminus. |
| Recombinant Human Siglec-6 Protein (HEK293, C-Fc)
Siglec-6, also known as CD327, mediates sialic-acid dependent binding to cells. Siglec-6 binds to alpha-2,6-linked sialic acid. |
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