All AbMole products are for research use only, cannot be used for human consumption.
CXCR4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 plays a role in both physiological and pathological conditions and it represents a crucial target in drug development. CXCL12 is the principal CXCR4 specific ligand and that the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) is also able to bind and activate CXCR4.
Recombinant Human CXCR4 expressed the target gene encoding Met1-Ser46 with a human IgG1 Fc tag at the N-terminus.
Loaded Recombinant Human CXCR4 on Pro-A Biosensor, can bind Recombinant Human CXCL12 with an affinity constant of 8.4 uM as determined in BLI assay.
Accession: P61073
Apparent Molecular Weight: 35-45 KDa, under reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from a 0.2 μm filtered solution of 50mM Tris-HCl, 100mM Glycine, pH7.5.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. |
| Recombinant Human SIGLEC-7 Protein (HEK293, His Tag)
Recombinant Human Sialic Acid-binding Ig-like Lectin 7 expressed the target gene encoding the Human SIGLEC7 (Q9Y286-1) (Met1-Leu353) was expressed with a polyhistidine tag at the C-terminus. The recombinant Human SIGLEC7 consists of 346 amino acids and predicts a molecular mass of 38.4 kDa. |
| Recombinant Human Siglec-7 Protein (HEK293, C-6His)
Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. |
| Recombinant Human SIGLEC-10 Protein (HEK293, mFc Tag)
The recombinant human SIGLEC-10 comprises 763 amino acids and has a calculated molecular mass of 84.60 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Thr546) was expressed with the Fc region of mouse IgG2a at the C-terminus. |
| Recombinant Human SIGLEC-10 Protein (HEK293, His Tag)
The recombinant human SIGLEC-10 consists of 540 amino acids and predicts a molecular mass of 59.5 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Asn550) was expressed with a polyhistidine tag at the C-terminus. |
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Products are for research use only. Not for human use. We do not sell to patients.
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