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Siglec-15 is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo.
Recombinant Mouse Siglec-15 expressed the target gene encoding Arg24-Thr262 with a 6His tag at the C-terminus.
Immobilized Recombinant Mouse Siglec-15 at 2 μg/mL can bind Anti-Siglec-15 antibody, the ED50 for this effect is 15.2 ng/mL.
Accession: A7E1W8
Apparent Molecular Weight: 30-40 KDa, reducing conditions
Endotoxin < 1 EU/µg
Tag Info: C-6His
Lyophilized from a 0.2 μm filtered solution of PBS, 150mM NaCl, 5% Thehalose, 0.3% Chaps, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Related Receptor Proteins Products |
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| Recombinant Human Siglec-15 Protein (HEK293, C-Fc)
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
| Recombinant Human Siglec-15 Protein (HEK293, C-mFc)
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
| Recombinant Human Siglec-9 Protein (HEK293, C-Fc)
Sialic acid-binding Ig-like lectin 9(Siglec 9) is expressed by peripheral blood leukocytes, and found in liver, fetal liver, bone marrow, placenta, spleen and so on. It is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It also binds to alpha-2,3- or alpha-2,6-linked sialic acid. |
| Recombinant Human Siglec-6 Protein (HEK293, C-Fc)
Siglec-6, also known as CD327, mediates sialic-acid dependent binding to cells. Siglec-6 binds to alpha-2,6-linked sialic acid. |
| Recombinant Human SIGLEC-10 Protein (HEK293, His Tag)
The recombinant human SIGLEC-10 consists of 540 amino acids and predicts a molecular mass of 59.5 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Asn550) was expressed with a polyhistidine tag at the C-terminus. |
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