Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M28591 | BMS-P5 | BMS-P5 is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model. |
| M21682 | BB-Cl-Amidine | BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor. |
| M19975 | GSK-121 Trifluoroacetate | GSK-121 Trifluoroacetate is a selective inhibitor of PAD4. |
| M19974 | GSK199 hydrochloride | GSK199 hydrochloride is a selective PAD4 inhibitor with half-maximum inhibitory concentration (IC50) values, in the absence of calcium, of 200 nM. |
| M13864 | Cl-amidine hydrochloride | Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. |
| M8603 | GSK484 hydrochloride | GSK484 hydrochloride is a potent selective reversible inhibitor of protein arginine deiminase PAD4, an enzyme believed to play a role in granulocyte and macrophage development leading to inflammation and immune response, and overexpressed in many tumors. |
| M58209 | Streptonigrin | Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively. Streptonigrin possesses both anti-tumor and anti-bacterial activity. |
| M41728 | PAD4-IN-2 | PAD4-IN-2 is a PAD4 inhibitor (IC50=1.94 μM). |
| M30880 | Cl-amidine | Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model. |
| M28778 | GSK106 | GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 and GSK199. |
| M28592 | BMS-P5 free base | BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 free base blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model. |
| M13863 | BB-Cl-Amidine hydrochloride | BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor. |
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