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Cl-amidine 

Cat. No. M30880

All AbMole products are for research use only, cannot be used for human consumption.

Cl-amidine  Structure

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Quality Control & Documentation
Biological Activity

Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.

Chemical Information
Molecular Weight 310.78
Formula C14H19ClN4O2
CAS Number 913723-61-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Ming Zhai, et al. Nat Commun. Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis

[2] Jianxin Du, et al. Hum Cell. Cl-amidine attenuates lipopolysaccharide-induced inflammation in human gingival fibroblasts via the JNK/MAPK, NF-κB, and Nrf2 signalling pathways

[3] Dina Ahmed, et al. Int J Mol Sci. Controlled Delivery of Pan-PAD-Inhibitor Cl-Amidine Using Poly(3-Hydroxybutyrate) Microspheres

[4] Chaoqun Wang, et al. Microb Pathog. Cl-amidine attenuates lipopolysaccharide-induced mouse mastitis by inhibiting NF-κB, MAPK, NLRP3 signaling pathway and neutrophils extracellular traps release

[5] Ali Z Siddiqui, et al. Surg Infect (Larchmt). Cl-Amidine Improves Survival and Attenuates Kidney Injury in a Rabbit Model of Endotoxic Shock

Related PAD Products
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GSK106 

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BMS-P5 

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  Catalog
Abmole Inhibitor Catalog




Keywords: Cl-amidine  supplier, PAD, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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