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Cl-amidine hydrochloride

Cat. No. M13864

All AbMole products are for research use only, cannot be used for human consumption.

Cl-amidine hydrochloride Structure
Size Price Availability Quantity
1mg USD 50  USD50 In stock
5mg USD 108  USD108 In stock
10mg USD 180  USD180 In stock
25mg USD 360  USD360 In stock
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Quality Control & Documentation
Biological Activity

Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine hydrochloride induces apoptosis in cancer cells. Cl-amidine hydrochloride induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.

Chemical Information
Molecular Weight 347.24
Formula C14H20Cl2N4O2
CAS Number 1373232-26-8
Form Solid
Solubility (25°C) DMSO 40 mg/mL
Water 50 mg/mL
Storage -20°C, sealed
Related PAD Products
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Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively. Streptonigrin possesses both anti-tumor and anti-bacterial activity.

PAD4-IN-2

PAD4-IN-2 is a PAD4 inhibitor (IC50=1.94 μM).

Cl-amidine 

Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.

GSK106 

GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 and GSK199.

BMS-P5 free base 

BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 free base blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model.

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Keywords: Cl-amidine hydrochloride supplier, PAD, inhibitors, activators

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