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GSK484 hydrochloride

Cat. No. M8603

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GSK484 hydrochloride Structure
Synonym:

GTPL8577; AOB6992

Size Price Availability Quantity
10mM*500uL in DMSO USD 120  USD120 In stock
1mg USD 70  USD70 In stock
5mg USD 160  USD160 In stock
10mg USD 245  USD245 In stock
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Quality Control & Documentation
Biological Activity

GSK484 hydrochloride is a potent selective reversible inhibitor of protein arginine deiminase PAD4, an enzyme believed to play a role in granulocyte and macrophage development leading to inflammation and immune response, and overexpressed in many tumors. GSK484 has IC50 values of 50 nM without calcium and 250 nM in the presence of 2 mM calcium. GSK484 showed minimal off-target activity tested against 50 other proteins with no activation across HDACs 1–11 even at 100 μM. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is reordered to form a β-hairpin.

Chemical Information
Molecular Weight 510.03
Formula C27H31N5O3.HCl
CAS Number 1652591-81-5
Solubility (25°C) DMSO 100 mg/mL
Water 50 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Zhiyang Wu, et al. Protectin D1 decreases pancreatitis severity in mice by inhibiting neutrophil extracellular trap formation

Related PAD Products
Streptonigrin

Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively. Streptonigrin possesses both anti-tumor and anti-bacterial activity.

PAD4-IN-2

PAD4-IN-2 is a PAD4 inhibitor (IC50=1.94 μM).

Cl-amidine 

Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.

GSK106 

GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 and GSK199.

BMS-P5 free base 

BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 free base blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model.

  Catalog
Abmole Inhibitor Catalog




Keywords: GSK484 hydrochloride, GTPL8577; AOB6992 supplier, PAD, inhibitors, activators

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