Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M10346 | L-Glutamic acid | L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). |
| M18309 | p-Hydroxy-cinnamic acid | p-Hydroxy-cinnamic acid inhibits platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. |
| M6687 | Docosahexaenoic acid (Oil) | Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. Docosahexaenoic acid is a RXR agonist. |
| M9953 | Taurocholic acid | Taurocholic acid (N-Choloyltaurine) is a bile acid, which can be used in the emulsification of fats. |
| M10168 | L-Lactic acid | L-Lactic acid is an organic acid, which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. |
| M31283 | Glucose oxidase | Glucose oxidase (GOD) is an oxidoreductase enzyme that inhibits the proliferation of cancer cells by reacting with intracellular oxygen (O2) and β-D-glucose to produce hydrogen peroxide (H2O2) and gluconic acid, thereby cutting off the source of nutrients for cancer cells. |
| M9076 | NADPH tetrasodium salt | NADPH tetrasodium salt is a cofactor, used to donate electrons and a hydrogens to reactions catalyzed by some enzymes. NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. |
| M14386 | Maltol | Maltol, a type of aromatic compound, exists in high concentrations in red ginseng. Maltol is a potent antioxidative agent and typically is used to enhance flavor and preserve food. |
| M9905 | ATP disodium salt hydrate | ATP disodium salt hydrate is a disodium salt hydrate form of adenosine-triphosphate that is used in cells as a coenzyme. |
| M3292 | Adenosine | Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. |
| M66316 | Glycocholic acid hydrate | Glycocholic acid hydrate is a bile acid derivative. Glycocholic acid hydrate downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid hydrate inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis. |
| M66305 | Pyrroline-5-carboxylate sodium | Pyrroline-5-carboxylate sodium is an intermediate in the biosynthesis of proline and catabolism, and it plays a role in amino acid metabolism in organisms. |
| M66288 | 1-Oleoyl-sn-glycero-3-phosphocholine | 1-Oleoyl-sn-glycero-3-phosphocholine (18:1 Lyso PC), a lysophospholipid, is a GPR82 inhibitor. 1-Oleoyl-sn-glycero-3-phosphocholine contributes to adipocyte lipolysis regulation. 1-Oleoyl-sn-glycero-3-phosphocholine abrogates constitutive Gi-coupled GPR82 activity, shifts active/inactive equilibrium to inactive, suppresses Gi protein activation, increases cAMP production, and decreases GTPγS binding to Gαi proteins. |
| M66285 | 5-Methoxyindole-3-acetic acid | 5-Methoxyindole-3-acetic acid is a metabolite of melatonin, which can be isolated from pineal gland tissue. |
| M66284 | trans-3-Indoleacrylic acid | Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (M9060) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis. |
| M66196 | D-Glucose-1,2,3,4,5,6,6-d7 | D-Glucose-1,2,3,4,5,6,6-d7 is the deuterium labeled alpha-D-glucose. It is an endogenous metabolite. |
| M66006 | 14:0 Lyso PC | 14:0 Lyso PC (1-Myristoyl-sn-glycero-3-phosphocholine) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. |
| M65727 | Sodium gluconate | Sodium gluconate acts as a chelating agent. Sodium gluconate has been used as a component of recording buffer used in two-electrode voltage-clamp (TEVC) recording in Xenopus laevis oocytes. |
| M65722 | 20α-hydroxy progesterone | 20α-hydroxy progesterone is the metabolite of Progesterone. 20α-hydroxy progesterone inhibits cell proliferation and migration in breast tissue. |
| M59416 | CMP-Sialic acid sodium salt | CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. |
| M59292 | PMSG | PMSG (Pregnant mare serum gonadotropin) is a gonadotropin used to promote follicular development and ovulation in animals. PMSG exerts its regulatory effects by stimulating changes in blood hormones, gonadotropins, and cytoplasmic estradiol receptors in the anterior pituitary and hypothalamus. |
| M59273 | 2-Deoxy-D-galactose | 2-Deoxy-D-galactose is a glucose analog that inhibits glycolysis to inhibits tumor growth. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo. |
| M59257 | 3-Methyluridine | 3-Methyluridine is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. |
| M59179 | 1a,1b-dihomo Prostaglandin F2α | 1a,1b-dihomo Prostaglandin F2α (1a,1b-dihomo PGF2α) is a hypothetical product of adrenic acid in the COX pathway. |
| M59161 | Dihydrothymine | Dihydrothymine (5,6-Dihydro-5-methyluracil) is an intermediate breakdown product of thymine, comes from animal or plants. |
| M59121 | Lithium acetoacetate | Lithium acetoacetate (Acetoacetic acid lithium) is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Lithium acetoacetate induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. |
| M59096 | Gentisuric Acid | Gentisuric Acid is a metabolite of Aspirin, it is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C. |
| M59095 | 5α-Dihydroprogesterone | 5α-Dihydroprogesterone (5a-Pregnane-3,20-dione) is the endogenous progesterone metabolite. 5α-Dihydroprogesterone (5a-Pregnane-3,20-dione) decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerizes F-actin in MCF-7 breast cancer cells. |
| M59086 | Adenosine 2',3'-cyclic phosphate sodium | Adenosine 2',3'-cyclic phosphate sodium serves as an extracellular source of adenosine. The release of extracellular 2′,3′-cAMP occurs in response to injury. 2′,3′-cAMP may be used to study the distribution and specificity of its degrading enzymes in the context of unique biological activities. 2′,3′-cAMP may also be used to study apoptosis induced at the level of mitochondrial permeability transition pores. 2′,3′-cAMP is converted into 2′-AMP and 3′-AMP which inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors. |
| M59073 | 6α-Hydroxy Paclitaxel | 6α-Hydroxy Paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy Paclitaxel (6-Hydroxytaxol) retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. |
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