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L-Lactic acid

Cat. No. M10168
L-Lactic acid Structure
Size Price Availability Quantity
1g USD 66  USD66 In stock
5g USD 175  USD175 In stock
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Quality Control & Documentation
Biological Activity

L-Lactic acid is an organic acid, which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid.

Chemical Information
Molecular Weight 90.08
Formula C3H6O3
CAS Number 79-33-4
Solubility (25°C) DMSO 90 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Miroslav Pohanka. Biomed Res Int. D-Lactic Acid as a Metabolite: Toxicology, Diagnosis, and Detection

[2] Andrew Breithaupt, et al. Facial Plast Surg Clin North Am. Collagen Stimulators: Poly-L-Lactic Acid and Calcium Hydroxyl Apatite

[3] Veeresh Juturu, et al. Crit Rev Biotechnol. Microbial production of lactic acid: the latest development

[4] Sanjay P Keni, et al. Facial Plast Surg Clin North Am. Sculptra (injectable poly-L-lactic acid)

[5] Caroline M Perry. Am J Clin Dermatol. Poly-L-lactic acid

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