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Glutamic acid (L-Glutamic acid)

Cat. No. M10346
Glutamic acid (L-Glutamic acid) Structure
Size Price Availability Quantity
1g USD 20  USD20 In stock
5g USD 40  USD40 In stock
10g USD 50  USD50 In stock
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Biological Activity

L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

Product Citations
Chemical Information
Molecular Weight 147.13
Formula C5H9NO4
CAS Number 56-86-0
Solubility (25°C) Water 6 mg/mL warmed
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M F Giorguieff, et al. Neurosci Lett. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices

[2] H Tapiero, et al. Biomed Pharmacother. II. Glutamine and glutamate

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