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SR-4995 is a potent and selective ligand of α-β-hydrolase domain containing 5 (ABHD5) that activates adipose triglyceride lipase (ATGL) by dissociating ABHD5 from its inhibitory regulator, perilipin-1 (PLIN1) and PLIN5. SR-4995 directly binds to ABHD5 and prevents ABHD5 to PLIN1. SR-4995 induces lipolysis in adipocytes and muscle, avoiding PKA-dependent signaling.
| Molecular Weight | 355.45 |
| Formula | C19H21N3O2S |
| CAS Number | 891509-95-8 |
| Form | Powder |
| Solubility (25°C) | DMSO 2 mg/mL |
| Storage | -20°C, protect from light |
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