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Docosahexaenoic acid is a endogenous omega-3 fatty acid. Docosahexaenoic Acid (DHA) acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Docosahexaenoic Acid (DHA) activates all three RXR isoforms. DHA also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling.
Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex.
Cell Metab. 2024 Oct 18.
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex
Docosahexaenoic acid (Oil) purchased from AbMole
| Molecular Weight | 328.49 |
| Formula | C22H32O2 |
| CAS Number | 6217-54-5 |
| Solubility (25°C) | DMSO 70 mg/mL 0.1 M NaOH: 6 mg/mL |
| Storage | -20°C, protect from light, sealed |
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