Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M3486 | NPS-2143 | NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. |
| M21421 | Upacicalcet | Upacicalcet is a calcium-sensing receptor (CaSR) agonist being developed for the study of secondary hyperparathyroidism (SHPT). |
| M13919 | Calhex 231 hydrochloride | Calhex 231 hydrochloride is a CaSR inhibitor via negative allosteric modulation. |
| M11306 | Etelcalcetide hydrochloride | Etelcalcetide Hydrochloride (AMG 416 Hydrochloride) is a synthetic peptide that acts as a calcium-sensitive receptor (CaSR) activator. Etelcalcetide hydrochloride effectively reduces parathyroid hormone (PTH) concentration in patients with secondary hyperparathyroidism undergoing hemodialysis. |
| M10439 | Evocalcet | Evocalcet is a calcium-sensitive receptor (CaSR) agonist that may be used in studies related to hypercalcemia and secondary hyperparathyroidism. |
| M8518 | Calindol hydrochloride | Calindol is a calcimimetic Ca Sensing Receptor (CaSR) agonist. |
| M6190 | Calcium-Sensing Receptor Antagonists I | Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. |
| M5521 | Cinacalcet HCl | Cinacalcet Hcl (AMG-073) is an orally active, second-generation calcimimetic compound; AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism. |
| M5520 | Cinacalcet | Cinacalcet(AMG-073) is an orally active, second-generation calcimimetic compound; AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism. |
| M4524 | Ligustroflavone | Ligustroflavone, which can be extracted from Ligustrum lucidum, is a potential calcium sensitive receptor (CaSR) antagonist. Ligustroflavone has protective effect on diabetic osteoporosis mice. |
| M3954 | Strontium ranelate | Strontium ranelate, a therapeutic for osteoporosis, was thought to have a dual mode of action, simultaneously stimulating bone formation and reducing resorption. |
| M41001 | Encaleret | Encaleret is an orally active calcium-sensitive receptor (CaSR) antagonist for studies related to osteoporosis and autosomal dominant hypocalcemia (ADH1). |
| M29965 | SB-423562 | SB-423562 is a short-acting calcium-sensing receptor (CaR) antagonist. SB-423562 has the potential for osteoporosis research. |
| M29964 | SB-423557 | SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation. |
| M28089 | Etelcalcetide | Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis. |
| M6392 | AC 265347 | AC 265347 is a calcium-sensitive receptor (CaSR) agonist and orthosteric modulator (auto-PAM) with a functional affinity (pKB) of 5.1.AC 265347 is used in the study of hyperparathyroidism and related disorders. |
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