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Ligustroflavone

Cat. No. M4524
Ligustroflavone Structure
Size Price Availability Quantity
20mg USD 300  USD300 In stock
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Biological Activity

Ligustroflavone, which can be extracted from Ligustrum lucidum, is a potential calcium sensitive receptor (CaSR) antagonist. Ligustroflavone has protective effect on diabetic osteoporosis mice.

Chemical Information
Molecular Weight 724.66
Formula C33H40O18
CAS Number 260413-62-5
Form Solid
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rong Kang, et al. Ligustroflavone ameliorates CCl 4-induced liver fibrosis through down-regulating the TGF-β/Smad signaling pathway

[2] Yi-Yue Zhang, et al. Ligustroflavone reduces necroptosis in rat brain after ischemic stroke through targeting RIPK1/RIPK3/MLKL pathway

[3] Rui Feng, et al. Protective Effects of Ligustroflavone, an Active Compound from Ligustrum lucidum, on Diabetes-Induced Osteoporosis in Mice: A Potential Candidate as Calcium-Sensing Receptor Antagonist

[4] Hong Liu, et al. Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study

[5] A Pieroni, et al. Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L

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Keywords: Ligustroflavone supplier, Calcium-sensing Receptor, inhibitors, activators

 
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