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Encaleret is an orally active calcium-sensitive receptor (CaSR) antagonist for studies related to osteoporosis and autosomal dominant hypocalcemia (ADH1).
| Molecular Weight | 514.03 |
| Formula | C29H33ClFNO4 |
| CAS Number | 787583-71-5 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Calcium-sensing Receptor Products |
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| SB-423562
SB-423562 is a short-acting calcium-sensing receptor (CaR) antagonist. SB-423562 has the potential for osteoporosis research. |
| SB-423557
SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation. |
| Etelcalcetide
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis. |
| Upacicalcet
Upacicalcet is a calcium-sensing receptor (CaSR) agonist being developed for the study of secondary hyperparathyroidism (SHPT). |
| Calhex 231 hydrochloride
Calhex 231 hydrochloride is a CaSR inhibitor via negative allosteric modulation. |
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