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Evocalcet

Cat. No. M10439

All AbMole products are for research use only, cannot be used for human consumption.

Evocalcet Structure
Synonym:

KHK7580; MT-4580

Size Price Availability Quantity
10mM*1mL in DMSO USD 56  USD56 In stock
2mg USD 32  USD32 In stock
5mg USD 52  USD52 In stock
10mg USD 85  USD85 In stock
50mg USD 245  USD245 In stock
100mg USD 374  USD374 In stock
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Quality Control & Documentation
Biological Activity

Evocalcet is a calcium-sensing receptor agonist. CaSR plays a key role in gastrointestinal physiological function and in the occurrence of digestive disease. High dietary Ca2+ may stimulate CaSR activation and could both inhibit tumor development and increase the chemotherapeutic sensitivity of cancer cells in colon cancer tissues.

Chemical Information
Molecular Weight 374.48
Formula C24H26N2O2
CAS Number 870964-67-3
Solubility (25°C) DMSO ≥ 10 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mariko Sakai, et al. PLoS One. Evocalcet prevents ectopic calcification and parathyroid hyperplasia in rats with secondary hyperparathyroidism

[2] Tadao Akizawa, et al. Ther Apher Dial. Evocalcet: A New Oral Calcimimetic for Dialysis pаtιепts With Secondary Hyperparathyroidism

[3] Hiroshi Miyazaki, et al. Bioorg Med Chem Lett. Discovery of evocalcet, a next-generation calcium-sensing receptor agonist for the treatment of hyperparathyroidism

[4] Takehisa Kawata, et al. PLoS One. A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro

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Keywords: Evocalcet, KHK7580; MT-4580 supplier, Calcium-sensing Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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