| Cat.No. | Name | Information |
|---|---|---|
| M21810 | Govorestat | Govorestat (AT-007) is a central nervous system (CNS)-permeable aldose reductase inhibitor that prevents the conversion of glucose to sorbitol and may be used in studies related to neurological disorders. |
| M18249 | Quercetin 3-gentiobioside | Quercetin 3-gentiobioside is isolated from A. iwayomogi, AR and AGE formation inhibitor, demonstrates biological activities against Aldose reductase (AR) and the formation of advanced glycation endproducts (AGEs). |
| M13426 | Danshenol B | Danshenol B has aldose reductase (AR) inhibitory activity. |
| M11067 | Ganoderic acid C6 | Ganoderic acid C6 has inhibited aldose reductase activity. |
| M11063 | Ganoderic acid C2 | Ganoderic acid C2 is a biologically active triterpenoid in Ganoderic acid C2 with potential anti-tumor biological activity, with antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 has a high inhibitory activity against rat lens aldose reductase (RLAR), which IC50 The value is 3.8 μM. |
| M9725 | Ponalrestat | Ponalrestat is an orally active, selective and noncompetitive aldose reductase inhibitor. |
| M4731 | Poliumoside | Poliumoside, a coffee-acylated phenylpropane glycoside isolated from the stems and leaves of Brandisia hancei. Poliumoside inhibited the formation of advanced glycation end products (AGE) and rat lens aldose reductase (RLAR) with IC50 values of 19.69 and 8.47 μM, respectively. Poliumoside also has anti-inflammatory and antioxidant activities. |
| M4333 | Calceolarioside-B | Calceolarioside B is a natural product isolated from the Stauntonia hexaphylla leaf. Calceolarioside B showed significant inhibitory activity against aldose reductase (RLAR) in rat lens with IC50 value of 23.99 μM. Calceolarioside B could effectively inhibit DPPH radical scavenging activity with IC50 value of 94.60 μM. |
| M4158 | Soyasaponin-Bb | Soyasaponin Bb is a soybean saponin isolated from the legume family that acts asa differential inhibitor of aldose reductase (ARDI). |
| M4010 | Isoliquiritigenin | Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM. |
| M56589 | Tolrestat | Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM. |
| M56588 | Exisulind | Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. |
| M42283 | AKR1C3-IN-10 | AKR1C3-IN-10 is a selective AKR1C3 inhibitor (IC50=51 nM). |
| M42282 | Dehydroglyasperin D | Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). |
| M42281 | Ganoderic acid Df | Ganoderic acid Df is a lanostane-type triterpenoid, that can be isolated from the fruiting body of Ganoderma lucidum. |
| M39052 | Danshenol A | Danshenol A is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. |
| M39051 | Hydroxyevodiamine | Hydroxyevodiamine (Rhetsinine) inhibits aldose reductase with an IC50 value of 24.1 μM. |
| M30830 | Imirestat | Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes. |
| M28233 | Caficrestat | Caficrestat (Aldose reductase-IN-1) is a inhibitor of aldose reductase with IC50 of 28.9 pM. |
| M17942 | 4-[2-(β-D-Glucopyranosyloxy)ethyl]-4-hydroxy-2,5-cyclohexadien-1-one (Cornoside) | 4-[2-（β-D-Glucopyranosyloxy）ethyl]-4-hydroxy-2,5-cyclohexadien-1-one（Cornoside） |
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