All AbMole products are for research use only, cannot be used for human consumption.
Ponalrestat is an orally active, selective and noncompetitive aldose reductase inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice. Ponalrestat is effective in the attenuation of the cachectic symptoms induced by human melanomas G361 and SEKI in nude mice.
| Molecular Weight | 391.19 |
| Formula | C17H12BrFN2O3 |
| CAS Number | 72702-95-5 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Aldose Reductase Products |
|---|
| Tolrestat
Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM. |
| Exisulind
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. |
| AKR1C3-IN-10
AKR1C3-IN-10 is a selective AKR1C3 inhibitor (IC50=51 nM). |
| Dehydroglyasperin D
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). |
| Ganoderic acid Df
Ganoderic acid Df is a lanostane-type triterpenoid, that can be isolated from the fruiting body of Ganoderma lucidum. |
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