Calceolarioside B is a natural product isolated from the Stauntonia hexaphylla leaf. Calceolarioside B showed significant inhibitory activity against aldose reductase (RLAR) in rat lens with IC50 value of 23.99 μM. Calceolarioside B could effectively inhibit DPPH radical scavenging activity with IC50 value of 94.60 μM.
Molecular Weight | 478.45 |
Formula | C23H26O11 |
CAS Number | 105471-98-5 |
Form | Solid |
Solubility (25°C) | DMSO ≥ 200 mg/mL |
Storage | -20°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Vanessa Winiewski, et al. Three new naphthoquinones from the tubers of Sinningia mauroana
[4] Hui-Min Gao, et al. Determination of calceolarioside B in Caulis Akebiae by RP-HPLC
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