Poliumoside, a coffee-acylated phenylpropane glycoside isolated from the stems and leaves of Brandisia hancei. Poliumoside inhibited the formation of advanced glycation end products (AGE) and rat lens aldose reductase (RLAR) with IC50 values of 19.69 and 8.47 μM, respectively. Poliumoside also has anti-inflammatory and antioxidant activities.
| Molecular Weight | 770.73 |
| Formula | C35H46O19 |
| CAS Number | 94079-81-9 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Gabriel R Martins, et al. Antifungal Phenylpropanoid Glycosides from Lippia rubella
| Related Aldose Reductase Products |
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AKR1C3-IN-10 is a selective AKR1C3 inhibitor (IC50=51 nM). |
| Dehydroglyasperin D
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). |
| Ganoderic acid Df
Ganoderic acid Df is a lanostane-type triterpenoid, that can be isolated from the fruiting body of Ganoderma lucidum. |
| Danshenol A
Danshenol A is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. |
| Hydroxyevodiamine
Hydroxyevodiamine (Rhetsinine) inhibits aldose reductase with an IC50 value of 24.1 μM. |
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