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ATM/ATR

Inhibitors

Cat.No.  Name Information
M3115 VE-822 (Berzosertib) VE-822 (Berzosertib) is an ATR inhibitor with IC50 of 19 nM.
M2412 AZ20 AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR.
M1998 KU-60019 KU-60019 is a potent ATM kinase inhibitor with IC50 of 6.3 nM.
M5138 Mirin Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.
M13590 KU-60019 KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.
M13589 Elimusertib hydrochloride Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM.
M11251 Gartisertib Gartisertib (VX-803) is an ATP-competitive, orally active, selective ATR inhibitor with Ki<150 pM. Gartisertib inhibits atR-driven phosphorylation of checkpoint kinase-1 (Chk1) with an IC50 value of 8 nM. It has antitumor activity.
M11017 RP-3500 RP-3500 (ATR inhibitor 4) is an orally potent, selective ATR kinase inhibitor (ATRi) in biochemical assays IC50 1.00 nM. The RP-3500 is 30 times more selective to ATR (IC).50=120 nM), which is 2,000 times > ATM, DNA-PK, and PI3Kα kinase.
M10158 AZ32 AZ32 is an orally bioavailable and blood-brain barrier-(BBB)penetrating inhibitor of ATM with IC50 of <6.2 nM and 0.31 μM for ATM enzyme in cell.
M10130 AZD0156 AZD0156 is a potent, selective and orally active ATM inhibitor with an IC50 of 0.58 nM. AZD0156 inhibits ATM mediated signal transduction, prevents DNA damage checkpoint activation, damages DNA damage repair, and induces tumor cell apoptosis.
M9581 AZD1390 AZD1390 is currently the most effective and highly selective ATM inhibitor with an IC50 of 0.78 nM, oral activity and the ability to cross the blood-brain barrier. In vivo, AZD1390 combined with radiotherapy effectively inhibited tumor growth.
M9128 AZ31 AZ31 is a potent and highly selective ATM inhibitor.
M8914 Ceralasertib(AZD6738) AZD6738 is an orally active, selective ATR kinase inhibitor with an IC50 of 1 nM. AZD6738 inhibits ATR kinase activity and impels cell viability. AZD6738 induces rapid cell death in tumor cells with an ATM gene defect.
M6080 Elimusertib (BAY-1895344) Elimusertib (BAY-1895344) is an effective, oral, selective ATR inhibitor with an IC50 value of 7 nM and antitumor activity. Elimusertib (Bay-1895344) showed antitumor activity against A2780 ovarian cancer, PC-3 prostate cancer, LOVO colorectal cancer and REC-1 suite cell lymphoma, and was most sensitive to lymphoma.
M5138 Mirin Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.
M3570 Candesartan Cilexetil Candesartan Cilexetil is a specific nonpeptide Ang II receptor (ATR) antagonist and the procompound of candesartan which is an ATR antagonist with an IC50 of 15 μg/kg.
M3115 VE-822 (Berzosertib) VE-822 (Berzosertib) is an ATR inhibitor with IC50 of 19 nM.
M2505 CGK 733 CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.
M2412 AZ20 AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR.
M2309 CP-466722 Cp-466722 is a reversible ATM inhibitor with IC50 value of 4.1 μM, but has no effect on PI3K, PIKK family proteins.
M2187 ETP-46464 ETP-46464 is a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα and ATM with IC50 of 0.6, 14, 36, 170 and 545 nM, respectively.
M2047 VE-821 VE-821 is a highly selective and potent ATR inhibitor with IC50 of 26 nM.
M1998 KU-60019 KU-60019 is a potent ATM kinase inhibitor with IC50 of 6.3 nM.
M1801 KU-55933 KU-55933 is a cell-permeable ATP-competitive inhibitor of ATM (IC50 = 13 nM; Ki = 2.2 nM) with selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 μM for DNAPK, mTOR, PI 3-K, respectively; IC50 > 100 μM for PI 4-K and ATR).



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