| Cat.No. | Name | Information |
|---|---|---|
| M5138 | Mirin | Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity. |
| M2412 | AZ20 | AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR. |
| M1998 | KU-60019 | KU-60019 is a potent ATM kinase inhibitor with IC50 of 6.3 nM. |
| M1801 | KU-55933 | KU-55933 is a cell-permeable ATP-competitive inhibitor of ATM (IC50 = 13 nM; Ki = 2.2 nM) with selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 μM for DNAPK, mTOR, PI 3-K, respectively; IC50 > 100 μM for PI 4-K and ATR). |
| M54526 | Tuvusertib | Tuvusertib is a selective and orally active ATR inhibitor that kills tumor cells by preventing the repair of damaged DNA with a Ki value below 1 μΜ. |
| M11251 | Gartisertib | Gartisertib (VX-803) is an ATP-competitive, orally active, selective ATR inhibitor with Ki<150 pM. Gartisertib inhibits atR-driven phosphorylation of checkpoint kinase-1 (Chk1) with an IC50 value of 8 nM. It has antitumor activity. |
| M11017 | Camonsertib (RP-3500) | Camonsertib (RP-3500) is an orally potent, selective ATR kinase inhibitor (ATRi) in biochemical assays IC50 1.00 nM. The RP-3500 is 30 times more selective to ATR (IC).50=120 nM), which is 2,000 times > ATM, DNA-PK, and PI3Kα kinase. |
| M10158 | AZ32 | AZ32 is an orally bioavailable and blood-brain barrier-(BBB)penetrating inhibitor of ATM with IC50 of <6.2 nM and 0.31 μM for ATM enzyme in cell. |
| M10130 | AZD0156 | AZD0156 is a potent, selective and orally active ATM inhibitor with an IC50 of 0.58 nM. AZD0156 inhibits ATM mediated signal transduction, prevents DNA damage checkpoint activation, damages DNA damage repair, and induces tumor cell apoptosis. |
| M9581 | AZD1390 | AZD1390 is currently the most effective and highly selective ATM inhibitor with an IC50 of 0.78 nM, oral activity and the ability to cross the blood-brain barrier. In vivo, AZD1390 combined with radiotherapy effectively inhibited tumor growth. |
| M9128 | AZ31 | AZ31 is a potent and highly selective ATM inhibitor. |
| M8914 | Ceralasertib (AZD6738) | Ceralasertib (AZD6738) is an orally active, selective ATR kinase inhibitor with an IC50 of 1 nM. AZD6738 inhibits ATR kinase activity and impels cell viability. AZD6738 induces rapid cell death in tumor cells with an ATM gene defect. |
| M6080 | Elimusertib (BAY-1895344) | Elimusertib (BAY-1895344) is an effective, oral, selective ATR inhibitor with an IC50 value of 7 nM and antitumor activity. Elimusertib (Bay-1895344) showed antitumor activity against A2780 ovarian cancer, PC-3 prostate cancer, LOVO colorectal cancer and REC-1 suite cell lymphoma, and was most sensitive to lymphoma. |
| M4621 | Garcinone-C | Garcinone C is a xanthone derivative, a natural compound extracted from Garcinia oblongifolia Champ. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while effectively inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, CDC2, Stat3 and CDK7. |
| M3570 | Candesartan Cilexetil | Candesartan Cilexetil is a specific nonpeptide Ang II receptor (ATR) antagonist and the procompound of candesartan which is an ATR antagonist with an IC50 of 15 μg/kg. |
| M2505 | CGK 733 | CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM. |
| M2309 | CP-466722 | Cp-466722 is a reversible ATM inhibitor with IC50 value of 4.1 μM, but has no effect on PI3K, PIKK family proteins. |
| M2187 | ETP-46464 | ETP-46464 is a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα and ATM with IC50 of 0.6, 14, 36, 170 and 545 nM, respectively. |
| M2047 | VE-821 | VE-821 is a highly selective and potent ATR inhibitor with IC50 of 26 nM. |
| M55925 | ART0380 | ART0380 is a potent and selective ATR kinase inhibitor. |
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