|M6080||BAY-1895344||Identification of potent, highly selective and orally available ATR inhibitor BAY 1895344 with favorable PK properties and promising efficacy in monotherapy and combination in preclinical tumor models|
|M5138||Mirin||Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.|
|M3570||Candesartan Cilexetil||Candesartan Cilexetil is a specific nonpeptide Ang II receptor (ATR) antagonist and the procompound of candesartan which is an ATR antagonist with an IC50 of 15 μg/kg.|
|M3115||VE-822||VE-822 is an ATR inhibitor with IC50 of 19 nM.|
|M2505||CGK 733||CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.|
|M2412||AZ20||AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR.|
|M2309||CP-466722||CP-466722 is an potent and reversible ATM inhibitor.|
|M2187||ETP-46464||ETP-46464 is a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα and ATM with IC50 of 0.6, 14, 36, 170 and 545 nM, respectively.|
|M2047||VE-821||VE-821 is a highly selective and potent ATR inhibitor with IC50 of 26 nM.|
|M1998||KU-60019||KU-60019 is a potent ATM kinase inhibitor with IC50 of 6.3 nM.|
|M1801||KU-55933||KU-55933 is a cell-permeable ATP-competitive inhibitor of ATM (IC50 = 13 nM; Ki = 2.2 nM) with selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 μM for DNAPK, mTOR, PI 3-K, respectively; IC50 > 100 μM for PI 4-K and ATR).|
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