Catalog

ATM/ATR

Inhibitors

Cat.No.	Name	Information
M6080	BAY-1895344	Identification of potent, highly selective and orally available ATR inhibitor BAY 1895344 with favorable PK properties and promising efficacy in monotherapy and combination in preclinical tumor models
M5138	Mirin	Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.
M3570	Candesartan Cilexetil	Candesartan Cilexetil is a specific nonpeptide Ang II receptor (ATR) antagonist and the procompound of candesartan which is an ATR antagonist with an IC50 of 15 μg/kg.
M3115	VE-822	VE-822 is an ATR inhibitor with IC50 of 19 nM.
M2505	CGK 733	CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.
M2412	AZ20	AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR.
M2309	CP-466722	CP-466722 is an potent and reversible ATM inhibitor.
M2187	ETP-46464	ETP-46464 is a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα and ATM with IC50 of 0.6, 14, 36, 170 and 545 nM, respectively.
M2047	VE-821	VE-821 is a highly selective and potent ATR inhibitor with IC50 of 26 nM.
M1998	KU-60019	KU-60019 is a potent ATM kinase inhibitor with IC50 of 6.3 nM.
M1801	KU-55933	KU-55933 is a cell-permeable ATP-competitive inhibitor of ATM (IC50 = 13 nM; Ki = 2.2 nM) with selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 μM for DNAPK, mTOR, PI 3-K, respectively; IC50 > 100 μM for PI 4-K and ATR).