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AZD1390

Cat. No. M9581
AZD1390 Structure
Synonym:

AZD-1390

Size Price Availability Quantity
5mg USD 190  USD190 In stock
10mg USD 290  USD290 In stock
25mg USD 560  USD560 In stock
50mg USD 980  USD980 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AZD1390 is currently the most effective and highly selective ATM inhibitor with an IC50 of 0.78 nM, oral activity and the ability to cross the blood-brain barrier. In vivo, AZD1390 combined with radiotherapy effectively inhibited tumor growth.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 477.57
Formula C27H32FN5O2
CAS Number 2089288-03-7
Purity >99%
Solubility DMSO ≥ 15 mg/mL (May need warming)
Storage at -20°C
References

[1] Stephen T Durant, et al. Sci Adv. The Brain-Penetrant Clinical ATM Inhibitor AZD1390 Radiosensitizes and Improves Survival of Preclinical Brain Tumor Models

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Keywords: AZD1390, AZD-1390 supplier, ATM/ATR, inhibitors

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