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CGK 733

Cat. No. M2505
CGK 733 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 55  USD55 In stock
10mg USD 75  USD75 In stock
50mg USD 330  USD330 In stock
100mg USD 540  USD540 In stock
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Quality Control & Documentation
Biological Activity

CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.

Chemical Information
Molecular Weight 555.84
Formula C23H18Cl3FN4O3S
CAS Number 905973-89-9
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ming Wang, et al. In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells

[2] Andrea Balogh, et al. The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair

[3] Christian Jekimovs, et al. Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising

[4] Melissa Li Fang Tang, et al. The DNA damage response induces antigen presenting cell-like functions in fibroblasts

[5] Terence M Williams, et al. Molecular imaging of the ATM kinase activity

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  Catalog
Abmole Inhibitor Catalog




Keywords: CGK 733 supplier, ATM/ATR, inhibitors, activators


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