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CGK 733

Cat. No. M2505
CGK 733 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 75  USD75 In stock
10mg USD 70  USD70 In stock
50mg USD 290  USD290 In stock
100mg USD 480  USD480 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 555.84
Formula C23H18Cl3FN4O3S
CAS Number 905973-89-9
Purity >98%
Solubility DMSO 90 mg/mL
Storage at -20°C
References

[1] Ming Wang, et al. In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells

[2] Andrea Balogh, et al. The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair

[3] Christian Jekimovs, et al. Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising

[4] Melissa Li Fang Tang, et al. The DNA damage response induces antigen presenting cell-like functions in fibroblasts

[5] Terence M Williams, et al. Molecular imaging of the ATM kinase activity

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RP-3500

RP-3500 (ATR inhibitor 4) is an orally potent, selective ATR kinase inhibitor (ATRi) in biochemical assays IC50 1.00 nM. The RP-3500 is 30 times more selective to ATR (IC).50=120 nM), which is 2,000 times > ATM, DNA-PK, and PI3Kα kinase.

AZ32

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Keywords: CGK 733 supplier, ATM/ATR, inhibitors

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