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Camonsertib (RP-3500)

Cat. No. M11017
Camonsertib (RP-3500) Structure
Synonym:

ATR inhibitor 4; Camonsertib

Size Price Availability Quantity
5mg USD 620  USD620 In stock
10mg USD 980  USD980 In stock
25mg USD 1600  USD1600 In stock
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Quality Control & Documentation
Biological Activity

Camonsertib (RP-3500) is an orally potent, selective ATR kinase inhibitor (ATRi) in biochemical assays IC50 1.00 nM. The RP-3500 is 30 times more selective to ATR (IC).50=120 nM), which is 2,000 times > ATM, DNA-PK, and PI3Kα kinase.

Chemical Information
Molecular Weight 410.47
Formula C21H26N6O3
CAS Number 2417489-10-0
Solubility (25°C) DMSO 45 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Anne Roulston, et al. Mol Cancer Ther. RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors

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  Catalog
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Keywords: Camonsertib (RP-3500), ATR inhibitor 4; Camonsertib supplier, ATM/ATR, inhibitors, activators


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