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AZ20

Cat. No. M2412
AZ20 Structure
Size Price Availability Quantity
5mg USD 130 In stock
10mg USD 210 In stock
25mg USD 400 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM, 8-fold selectivity over mTOR. In vitro, AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Prolonged exposure with AZ20 increases  H2AX pan-nuclear staining, indicative of replication stress. AZ20 induces growth inhibition and cell death and its profile of activity is distinctly when compares with other cytotoxic agents. in vivo,AZ20 induces significant tumour growth inhibition at well tolerated doses.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 412.51
Formula C21H24N4O3S
CAS Number 1233339-22-4
Purity >99%
Solubility DMSO 70 mg/mL
Storage at -20°C
References

Abstract 1823: AZ20, a novel potent and selective inhibitor of ATR kinase with in vivo antitumour activity.
Foote KM, et al. J Med Chem. 2013 Mar 14;56(5):2125-38. PMID: 23394205.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AZ20 supplier, ATM/ATR, inhibitors

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