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Gartisertib

Cat. No. M11251
Gartisertib Structure
Synonym:

VX-803; M4344; ATR inhibitor 2

Size Price Availability Quantity
5mg USD 420  USD420 In stock
10mg USD 690  USD690 In stock
50mg USD 1960  USD1960 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Gartisertib (VX-803) is an ATP-competitive, orally active, selective ATR inhibitor with Ki<150 pM. Gartisertib inhibits atR-driven phosphorylation of checkpoint kinase-1 (Chk1) with an IC50 value of 8 nM. It has antitumor activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 541.55
Formula C25H29F2N9O3
CAS Number 1613191-99-3
Purity >99%
Solubility DMSO ≥ 10 mg/mL
Storage at -20°C
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Keywords: Gartisertib, VX-803; M4344; ATR inhibitor 2 supplier, ATM/ATR, inhibitors

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