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CP-466722

Cat. No. M2309
CP-466722 Structure
Synonym:

CP466722

Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 145  USD145 In stock
50mg USD 385  USD385 In stock
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Quality Control
Biological Activity

Cp-466722 is a reversible ATM inhibitor with IC50 value of 4.1 μM, but has no effect on PI3K, PIKK family proteins.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 349.35
Formula C17H15N7O2
CAS Number 1080622-86-1
Purity 99.5%
Solubility DMSO
Storage at -20°C
References

[1] Mei Hua Jin, et al. ATM in DNA repair in cancer

[2] Rodrigo Martinez-Monedero, et al. GluA2-Containing AMPA Receptors Distinguish Ribbon-Associated from Ribbonless Afferent Contacts on Rat Cochlear Hair Cells

[3] Aditi Nadkarni, et al. ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells

[4] Michael D Rainey, et al. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation

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Keywords: CP-466722, CP466722 supplier, ATM/ATR, inhibitors

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