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 About 15 results found for searched term "VE-PTP-IN-1" (0.208 seconds)

Cat.No.  Name Target
M42872 VE-PTP-IN-1 Others
VE-PTP-IN-1 is a weakly acidic and selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP).VE-PTP-IN-1 is assocaited with vascular homeostasis and angiogenesis.
M4596 Silydianin Phosphatase
Silydianin, the active ingredient of silythistle, has anti-collagenase and anti-elastic enzyme activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 17.38 μM. Silydianin inhibited the production and release of oxidation products in vitro.
M10739 SPI-112 Phosphatase
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor of SHP2, protein tyrosine phosphatase (PTP) and PTP1B IC50 1 μM, 18.3 μM, and 14.5 μM, respectively.
M11043 DJ001 Others
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor,IC50 is 1.43 μM. DJ001 has no inhibitory activity against other phosphatases and only moderate inhibitory activity against protein phosphatase 5. DJ001 Promotes hematopoietic stem cell regeneration.
M11444 ABBV-CLS-484 Phosphatase
Osunprotafib; AC484
ABBV-CLS-484 (Osunprotafib) is an first-in-class, orally active, potent PTPN2/PTPN1 active site inhibitor with an EC50 of 0.176 μM that enhances the sensitivity of tumor cells to IFNγ and promotes T cell activation and function.
M28513 DPM-1001  Phosphatase
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property.
M29012 ML 400  Phosphatase
ML 400 is a potent and selective LMPTP inhibitor with an IC50 value of 1680 nM. ML 400 inhibits adipogenesis.
M29054 JMS-053  Phosphatase
JMS-053 is a potent, selective and reversible PTP4A inhibitor, with IC50s of 29.1 nM, 48.0 nM, 34.7 nM, 92.6 nM, and 207.6 nM for PTP4A1, PTP4A2, PTP4A3, CDC25B, and DUSP3, respectively. JMS-053 can inhibit cancer cell migration and spheroid growth in vitro, attenuate in vivo ovarian tumor growth.
M30782 JUN-1111  Phosphatase
JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1.
M31059 DPM-1001 trihydrochloride  Phosphatase
DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property.
M41012 MptpB-IN-2 Antibiotic
MptpB-IN-2 is a selective mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with IC50s of 0.64 μM, 4.06 μM and 4.14 μM for MptpB, MptpA and PTP1B, respectively.
M42541 Tegeprotafib Phosphatase
Tegeprotafib (PTPN2/1-IN-1) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively.
M55024 Recombinant Human DPP4/CD26 (HEK293, C-6His) Enzymes & Regulators
Dipeptidyl Peptidase 4; DPP IV; ADCP-2
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner.
M56743 PTP1B-IN-3  Phosphatase
PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP.
M56734 PTP1B-IN-3 diammonium  Phosphatase
PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP.



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