About 15 results found for searched term "VE-PTP-IN-1" (0.208 seconds)
Cat.No. | Name | Target |
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M42872 | VE-PTP-IN-1 | Others |
VE-PTP-IN-1 is a weakly acidic and selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP).VE-PTP-IN-1 is assocaited with vascular homeostasis and angiogenesis. | ||
M4596 | Silydianin | Phosphatase |
Silydianin, the active ingredient of silythistle, has anti-collagenase and anti-elastic enzyme activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 17.38 μM. Silydianin inhibited the production and release of oxidation products in vitro. | ||
M10739 | SPI-112 | Phosphatase |
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor of SHP2, protein tyrosine phosphatase (PTP) and PTP1B IC50 1 μM, 18.3 μM, and 14.5 μM, respectively. | ||
M11043 | DJ001 | Others |
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor,IC50 is 1.43 μM. DJ001 has no inhibitory activity against other phosphatases and only moderate inhibitory activity against protein phosphatase 5. DJ001 Promotes hematopoietic stem cell regeneration. | ||
M11444 | ABBV-CLS-484 | Phosphatase |
Osunprotafib; AC484 | ||
ABBV-CLS-484 (Osunprotafib) is an first-in-class, orally active, potent PTPN2/PTPN1 active site inhibitor with an EC50 of 0.176 μM that enhances the sensitivity of tumor cells to IFNγ and promotes T cell activation and function. | ||
M28513 | DPM-1001 | Phosphatase |
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property. | ||
M29012 | ML 400 | Phosphatase |
ML 400 is a potent and selective LMPTP inhibitor with an IC50 value of 1680 nM. ML 400 inhibits adipogenesis. | ||
M29054 | JMS-053 | Phosphatase |
JMS-053 is a potent, selective and reversible PTP4A inhibitor, with IC50s of 29.1 nM, 48.0 nM, 34.7 nM, 92.6 nM, and 207.6 nM for PTP4A1, PTP4A2, PTP4A3, CDC25B, and DUSP3, respectively. JMS-053 can inhibit cancer cell migration and spheroid growth in vitro, attenuate in vivo ovarian tumor growth. | ||
M30782 | JUN-1111 | Phosphatase |
JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1. | ||
M31059 | DPM-1001 trihydrochloride | Phosphatase |
DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property. | ||
M41012 | MptpB-IN-2 | Antibiotic |
MptpB-IN-2 is a selective mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with IC50s of 0.64 μM, 4.06 μM and 4.14 μM for MptpB, MptpA and PTP1B, respectively. | ||
M42541 | Tegeprotafib | Phosphatase |
Tegeprotafib (PTPN2/1-IN-1) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively. | ||
M55024 | Recombinant Human DPP4/CD26 (HEK293, C-6His) | Enzymes & Regulators |
Dipeptidyl Peptidase 4; DPP IV; ADCP-2 | ||
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. | ||
M56743 | PTP1B-IN-3 | Phosphatase |
PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. | ||
M56734 | PTP1B-IN-3 diammonium | Phosphatase |
PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. |
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