About 8 results found for searched term "TRPA1-IN-2" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42262 | TRPA1-IN-2 | TRP Channel |
| TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM. | ||
| M2087 | HC-030031 | TRP Channel |
| HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 = 6.2 and 5.3 μM, respectively). | ||
| M5301 | (E)-Cardamonin | NLR |
| Alpinetin chalcone | ||
| (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. | ||
| M6466 | AS 1269574 | GPR/FFAR |
| AS1269574 is a potent, orally active GPR119 agonist with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates the TRPA1 cation channel and stimulates glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induced pancreatic β cells to secrete glucose-dependent insulin only under high glucose conditions. AS1269574 has potential for type 2 diabetes research. | ||
| M9263 | CY-09 | Pyroptosis |
| CY09 | ||
| CY-09 is a selective direct inhibitor of NLRP3 with anti-inflammatory and antidepressant activity, which inhibits inflammatory cytokine production and TRPA1 activation by inhibiting the activation of the NLRP3 inflammatory vesicle, thereby decreasing the intracellular Ca2+ level and reducing the pro-inflammatory polarization of macrophages, alleviating pain and injury in animals. In addition, CY-09 can inhibit pyroptosis. | ||
| M29788 | BAY-390 | TRP Channel |
| BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation. | ||
| M51058 | Wasabi Receptor Toxin | Others |
| Wasabi Receptor Toxin (WaTx) active TRPA1 by prolonged channel openings and decreased Ca2+ permeability. | ||
| M58386 | Moringin | TRP Channel |
| Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. | ||
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