About 8 results found for searched term "SRPK" (0.182 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3029 | SRPIN340 | SRPK |
| SRPK inhibitor | ||
| SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases. | ||
| M29190 | SRPKIN-1 | SRPK |
| SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect. | ||
| M3062 | TG003 | CDK |
| TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC. | ||
| M10598 | SPHINX31 | SRPK |
| SPHINX-31 | ||
| SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) with IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). | ||
| M20272 | WAY-652848 | SRPK |
| SPHINX | ||
| WAY-652848 is a selective inhibitor of SRPK1 with an IC50 value of 0.58 μM.WAY-652848 effectively reduces choroidal neovascularization (CNV) in vivo, and can be used in the study of age-related macular degeneration. | ||
| M27617 | CLK1/2-IN-3 | CDK |
| LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs. | ||
| M30022 | SRPIN803 | Casein Kinase |
| SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively. SRPIN803 exhibits antiangiogenic activity. SRPIN803 can be used for the research of age-related macular degeneration. | ||
| M49414 | MSC-1186 | SRPK |
| MSC-1186 is a highly selective pan-SRPK inhibitor with activity against SRPK1, SRPK2, and SRPK3 with IC50 values of 2.7 nM, 81 nM, and 0.6 nM, respectively.MSC-1186 can be used in cancer research. | ||
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