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SRPKIN-1 

Cat. No. M29190

All AbMole products are for research use only, cannot be used for human consumption.

SRPKIN-1  Structure

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Quality Control & Documentation
Biological Activity

SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect.

Chemical Information
Molecular Weight 472.53
Formula C27H21FN2O3S
CAS Number 2089226-94-6
Form Solid
Solubility (25°C) DMSO ≥ 110 mg/mL
Storage -20°C, dry, sealed
References

[1] Ho Tsoi, et al. Cancers (Basel). SRSF5 Regulates the Expression of BQ323636.1 to Modulate Tamoxifen Resistance in ER-Positive Breast Cancer

[2] John M Hatcher, et al. Cell Chem Biol. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform

Related SRPK Products
MSC-1186

MSC-1186 is a highly selective pan-SRPK inhibitor with activity against SRPK1, SRPK2, and SRPK3 with IC50 values of 2.7 nM, 81 nM, and 0.6 nM, respectively.MSC-1186 can be used in cancer research.

WAY-652848

WAY-652848 is a selective inhibitor of SRPK1 with an IC50 value of 0.58 μM.WAY-652848 effectively reduces choroidal neovascularization (CNV) in vivo, and can be used in the study of age-related macular degeneration.

SPHINX31

SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) with IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1).

SRPIN340

SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases.

  Catalog
Abmole Inhibitor Catalog




Keywords: SRPKIN-1  supplier, SRPK, inhibitors, activators

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