About 14 results found for searched term "Rho-Kinase-IN-2" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M49537 | Rho-Kinase-IN-2 | ROCK |
| Rho-Kinase-IN-2 is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM). | ||
| M1817 | Y-27632 dihydrochloride | ROCK |
| Y27632; Y-27632 2HCl | ||
| Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. In addition, Y-27632 inhibited LPA-induced entosis. | ||
| M1856 | Thiazovivin | ROCK |
| Thiazovivin is a selective small molecule Rho-associated kinase (ROCK) inhibitor which significantly improves (200-fold) the efficiency of iPSC generation from human fibroblasts. | ||
| M5260 | Hydroxyfasudil hydrochloride | ROCK |
| HA-1100 HCl | ||
| Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively. | ||
| M5269 | GSK180736A | ROCK |
| GSK180736 | ||
| GSK180736A, developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5. | ||
| M11034 | Netarsudil (AR-13324) 2HCl | ROCK |
| AR-13324 | ||
| Netarsudil (AR-13324) is a Rho-kinase (ROCK) inhibitor with Ki values of 0.2-10.3 nM with potential intraocular pressure (IOP) lowering activity that inhibits both the ROCK and Rho pathways and increases atrial humor (AH) outflow and lowers IOP via the trabecular pathway, and may be used in glaucoma-related studies. | ||
| M28062 | PF-4950834 | ROCK |
| PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration. | ||
| M28188 | Sovesudil | ROCK |
| PHP-201; AMA0076 | ||
| Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia. | ||
| M28366 | Verosudil | ROCK |
| AR-12286 | ||
| Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork. | ||
| M31008 | Sovesudil hydrochloride | ROCK |
| PHP-201 hydrochloride; AMA0076 hydrochloride | ||
| Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia. | ||
| M49525 | 3-(4-Pyridyl)indole | ROCK |
| 3-(4-Pyridyl)indole (Rockout) is a Rho-kinase (ROCK) inhibitor, with an IC50 of 25 μM. | ||
| M49531 | Glycyl H-1152 hydrochloride | ROCK |
| Glycyl H-1152 hydrochloride is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. | ||
| M49536 | Rho-Kinase-IN-1 | ROCK |
| Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008. | ||
| M49538 | ROCK2-IN-5 | ROCK |
| ROCK2-IN-5 is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. | ||
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