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Rho-Kinase-IN-2

Cat. No. M49537

All AbMole products are for research use only, cannot be used for human consumption.

Rho-Kinase-IN-2 Structure

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Quality Control & Documentation
Biological Activity

Rho-Kinase-IN-2 is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM).

Chemical Information
Molecular Weight 372.44
Formula C20H25FN4O2
CAS Number 2573071-18-6
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
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Y-33075 hydrochloride (Y-39983) is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.

SR-3677 dihydrochloride 

SR-3677 dihydrochloride is a potent and selective ROCK-I and ROCK-II inhibitor with an IC50 values of 56 nM and 3 nM.

Akt/ROCK-IN-1

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Scaff10-8

Scaff10-8, bound to RhoA, inhibits the AKAP-Lbc-mediated RhoA activation.

  Catalog
Abmole Inhibitor Catalog




Keywords: Rho-Kinase-IN-2 supplier, ROCK, inhibitors, activators

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