About 17 results found for searched term "PARP-1-IN-4" (0.164 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41575 | PARP1-IN-14 | PARP |
| PARP1-IN-14 is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. | ||
| M41578 | PARP-1-IN-4 | PARP |
| PARP-1-IN-4 is a PARP-1 inhibitor. | ||
| M4855 | BMN673 isomer | PARP |
| LT-674 | ||
| (8R,9S)-Talazoparib is the 8R,9S enantiomer of Talazoparib. (8R,9S)-Talazoparib is a PARP1 inhibitor with an IC50 value of 144 nM. | ||
| M10298 | AZD5305 | PARP |
| Saruparib; AZD-5305 | ||
| Saruparib (AZD5305) is a potent and oral active, second-generation PARP (highly selective PARP1) inhibitor with IC50 values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. | ||
| M10445 | Fluzoparib (SHR3162) | PARP |
| SHR3162; Fuzuopali; Fuzuloparibum | ||
| Fluzoparib (SHR3162) is an effective oral active PARP1 inhibitor (IC50=1.46±0.72 nM) with superior antitumor activity. Fluzoparib selectively inhibited the proliferation of homologous recombination repair (HR) deficient cells and sensitized HR deficient cells to cytotoxic drugs. Fluzoparib has good pharmacokinetic properties in vivo and can be used in cancer research. | ||
| M13712 | PARP1-IN-5 dihydrochloride | PARP |
| PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer. | ||
| M21446 | AZD-9574 | PPAR |
| AZD-9574 is a best-in-class, potent, blood-brain barrier permeable PARP1 inhibitor that exhibits >8000-fold selectivity for PARP1 over PARP2/3/5a/6.AZD-9574 selectively inhibits PARP1 at the SSB site.AZD-9574 is an anticancer AZD-9574 is an anticancer compound that can be used in HRD+ breast cancer and advanced solid malignant tumor studies. | ||
| M22487 | RBN-3143 | PARP |
| RBN3143 | ||
| RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. | ||
| M25444 | Senaparib | PARP |
| IMP4297; JS109 | ||
| Senaparib (IMP4297) is a highly potent, selective and orally active PARP1/2 inhibitor. Senaparib (IMP4297) exhibits strong antitumor activity. | ||
| M27685 | Niraparib (R-enantiomer) | PARP |
| MK 4827 (R-enantiomer) | ||
| Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM. | ||
| M28495 | MSC2504877 | PARP |
| M2912 | ||
| MSC2504877 (M2912) is a potent and orally active tankyrase inhibitor with IC50s of 0.0007, 0.0008, 0.54 µM for TNKS, TNKS2, PARP1, respectively. MSC2504877 increases the expression of AXIN2 and TNKS protein levels and decreases β-catenin levels. MSC2504877 shows anti-tumor activity. | ||
| M28932 | AZ9482 | PARP |
| AZ9482 is a triple PARP1/2/6 inhibitor, with IC50 values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively. | ||
| M29181 | PARP14 inhibitor H10 | PARP |
| PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis. | ||
| M29548 | PROTAC PARP1 degrader | PROTAC |
| PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM. | ||
| M29690 | SK-575-NEG | PARP |
| SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM. | ||
| M41360 | PARP-1/2-IN-2 | PARP |
| PARP-1/2-IN-2-IN-1 is a PARP1/2/CDK12 inhibitor (IC50: 34, 30 and 285 nM respectively). | ||
| M41572 | PARP-1-IN-3 | PARP |
| PARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
