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BMN673 isomer

Cat. No. M4855
BMN673 isomer Structure
Synonym:

LT-674

Size Price Availability Quantity
10mM*1mL in DMSO USD 125  USD125 In stock
5mg USD 150  USD150 In stock
10mg USD 220  USD220 In stock
50mg USD 500  USD500 In stock
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Quality Control & Documentation
Biological Activity

(8R,9S)-Talazoparib is the 8R,9S enantiomer of Talazoparib. (8R,9S)-Talazoparib is a PARP1 inhibitor with an IC50 value of 144 nM.

Chemical Information
CAS Number 1207456-00-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bing Wang, et al. Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymer䲧畸Ỵ畹㧀畷羹皖睑ꏰऒŤऒĀ

[2] Junko Murai, et al. Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib

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Keywords: BMN673 isomer, LT-674 supplier, PARP, inhibitors, activators


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