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SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM.
| Molecular Weight | 891 |
| Formula | C48H55FN8O8 |
| CAS Number | 2523017-04-9 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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