About 10 results found for searched term "Nrf2-IN-3" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42737 | Nrf2-IN-3 | Keap1-Nrf2 |
| Nrf2-IN-3 is a Nrf2 inhibitor. | ||
| M4428 | Senkyunolide-I | Caspase |
| Senkyunolide I can be isolated from Ligusticum chuanxiong Hort and is an antimigraine compound. Senkyunolide I protects rat brain from focal cerebral ischemia-perfusion injury by up-regulating P-ERK1/2, Nrf2/HO-1 and inhibiting Caspase 3. | ||
| M7182 | RA 839 | Keap1-Nrf2 |
| RA839 | ||
| RA 839 is a nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). RA 839 suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory. | ||
| M8692 | ML385 | Keap1-Nrf2 |
| ML-385 | ||
| ML385 was a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1. | ||
| M8767 | MIND4-17 | Others |
| MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2. | ||
| M14593 | Keap1-Nrf2-IN-1 | Keap1-Nrf2 |
| Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. | ||
| M28606 | CPUY192018 | Others |
| CPUY192018 is a potent Keap1-Nrf2-ARE inhibitor with an IC50 of 0.63 µM. CPUY192018 exhibits induction of Nrf2-dependent gene NQO1 at 100 µM. | ||
| M29429 | DI-1859 | E1/E2/E3 Enzyme |
| DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage. | ||
| M29455 | DDO-7263 | Keap1-Nrf2 |
| DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits of NLRP3 inflammasome activation. DDO-7263 exerts anti-inflammatory activity and has the potential for neurodegenerative diseases research, such as Parkinson's disease (PD). | ||
| M42728 | Microcystin-LY | Keap1-Nrf2 |
| Microcystin-LY acts as an activator of the Nrf2 pathway to induce oxidative stress response, and the induction effect is most obvious at 3μM.. | ||
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