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DDO-7263 

Cat. No. M29455

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DDO-7263  Structure

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Quality Control & Documentation
Biological Activity

DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits of NLRP3 inflammasome activation. DDO-7263 exerts anti-inflammatory activity and has the potential for neurodegenerative diseases research, such as Parkinson's disease (PD).

Chemical Information
Molecular Weight 273.24
Formula C14H9F2N3O
CAS Number 2254004-96-9
Form Solid
Solubility (25°C) DMSO 17.86 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jonas Rydfjord, et al. J Org Chem. Palladium-Mediated Synthesis of [Carbonyl-11C]acyl Amidines from Aryl Iodides and Aryl Bromides and Their One-Pot Cyclization to 11C-Labeled Oxadiazoles

[2] Zhen Dai, et al. J Med Chem. Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome

[3] Li-Li Xu, et al. Free Radic Biol Med. 5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells aga䲧瘀Ỵ瘁㧀痿羹皘

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  Catalog
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Keywords: DDO-7263  supplier, Keap1-Nrf2, inhibitors, activators

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