About 10 results found for searched term "NLRP3-IN-9" (0.138 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42022 | NLRP3-IN-19 | NLR |
| NLRP3-IN-19 (JT001) is a potent, specific and orally active inhibitor of NLRP3. | ||
| M42023 | NLRP3-IN-19 sodium | NLR |
| NLRP3-IN-19 (JT001) is a potent, specific and orally active inhibitor of NLRP3. | ||
| M42027 | NLRP3-IN-9 | NLR |
| NLRP3-IN-9 is a potent NLRP3 inhibitor. | ||
| M4578 | Oridonin | NLR |
| Isodonol；NSC-250682 | ||
| Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. | ||
| M8083 | MCC950 sodium salt (CP-456773) | Pyroptosis |
| CP-456773 sodium; CRID3 sodium salt | ||
| MCC950 (CP-456773) sodium salt is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. | ||
| M9263 | CY-09 | Pyroptosis |
| CY09 | ||
| CY-09 is a selective direct inhibitor of NLRP3 with anti-inflammatory and antidepressant activity, which inhibits inflammatory cytokine production and TRPA1 activation by inhibiting the activation of the NLRP3 inflammatory vesicle, thereby decreasing the intracellular Ca2+ level and reducing the pro-inflammatory polarization of macrophages, alleviating pain and injury in animals. In addition, CY-09 can inhibit pyroptosis. | ||
| M41991 | HMGB1-IN-1 | HMGB1 |
| HMGB1-IN-1 inhibits the HMGB1/NF-κB/NLRP3 pathway and also exhibits strong NO inhibition in RAW264.7 cells with an IC50 value of 15.9 ± 0.6 μM. anti-inflammatory activity. | ||
| M42018 | Selnoflast potassium | NLR |
| Selnoflast (potassium) is a NLRP3 inhibitor (extracted from patent WO2019008025). | ||
| M42020 | Selnoflast calcium | NLR |
| Selnoflast calcium is a NLRP3 inhibitor (extracted from patent WO2019008025). | ||
| M45373 | NLRP3/AIM2-IN-2 | NLR |
| NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome-dependent cellular pyroptosis, with an IC50 value of 0.2392 ± 0.0233 μM. | ||
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