About 15 results found for searched term "NF-κB-IN-8" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42748 | NF-κB-IN-8 | NF-κB |
| NF-κB-IN-8 competitively antagonizes LPS binding to MD-2. | ||
| M4066 | Ginsenoside-Rb3 | NF-κB |
| Gypenoside IV | ||
| Ginsenoside Rb3 is derived from Panax Notoginseng. Ginsenoside Rb3 inhibited NF-κB transcriptional activity induced by TNFα in 293T cell lines with IC50 of 8.2 μM. Ginsenoside Rb3 also inhibited the induction of COX-2 and iNOS mRNA. | ||
| M4075 | Ginsenoside-Rd | NF-κB |
| Gypenoside VIII | ||
| Ginsenoside Rd inhibited NF-κB transcriptional activity induced by TNFα with IC50 of 12.05±0.82 μM. Ginsenoside Rd inhibited the expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibited CYP2D6, CYP1A2, CYP3A4 and CYP2C9 with IC50 of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM and 85.1±9.1 μM, respectively. | ||
| M4523 | Specnuezhenide | NF-κB |
| Specnuezhenide ((8E)-Nuezhenide) was separated from the fruit of the ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) inhibited IL-1β -induced chondrocyte inflammation by inhibiting NF-κB and WNT /β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) showed anti-inflammatory effects in rat models of osteoarthritis (OA). | ||
| M4680 | Rubimaillin | NF-κB |
| Mollugin is Rubia Cordifolia L. Is a major bioactive ingredient in the. Mollugin has anticancer effects by inhibiting NF-κB activation induced by TNF-α. Mollugin can enhance the osteogenic effect of BMP-2 through the P38-Smad signaling pathway. | ||
| M22238 | Emetine dihydrochloride hydrate | Autophagy |
| Emetine dihydrochloride hydrate is an alkaloid that has been found in ipecac root and has diverse biological activities. Emetine inhibits NF-κB signaling induced by TNF-α or IL-1β (IC50s = 2 and 4.2 μM, respectively, in a cell-based β-lactamase reporter assay), increases caspase-3/7 activity in ME180 cells (EC50 = 1.1 μM), and is cytotoxic to HeLa cells. | ||
| M27932 | SRTCX1002 | Sirtuin |
| SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively. | ||
| M28589 | SP-100030 | NF-κB |
| SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA). | ||
| M29339 | SB-284851-BT | p38 MAPK |
| SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 µM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 µM) and BRD4 (1)(IC50=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET). | ||
| M38796 | Homobutein | Parasite |
| Homobutein is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation. | ||
| M39015 | Deoxysappanone B | p38 MAPK |
| Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage. | ||
| M39017 | Emodic acid | p38 MAPK |
| Emodic acid (NSC624610) inhibits the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP. | ||
| M40637 | TD-1092 | IAP |
| TD-1092 is a pan-inhibitor of apoptosis (IAP) degrader with two different types of E3 ligase conjugates, IAP and CRBN, that induces proteasomal degradation of cIAP2 and XIAP in a CRBN-dependent manner. TD1092 also activates apoptotic proteases (apoptosis 3/7) and leads to apoptosis by promoting IAP degradation. In addition, TD1092 also blocks the TNFα-mediated NF-κB signaling pathway and inhibits the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can be used as a PROTAC for cancer research. | ||
| M42741 | NF-κB-IN-9 | NF-κB |
| NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). | ||
| M55225 | PTD-p65-P1 Peptide TFA | NF-κB |
| PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis. | ||
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