About 17 results found for searched term "NF-κB-IN-8" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42748 | NF-κB-IN-8 | NF-κB |
| NF-κB-IN-8 competitively antagonizes LPS binding to MD-2. | ||
| M4066 | Ginsenoside-Rb3 | NF-κB |
| Gypenoside IV | ||
| Ginsenoside Rb3 is derived from Panax Notoginseng. Ginsenoside Rb3 inhibited NF-κB transcriptional activity induced by TNFα in 293T cell lines with IC50 of 8.2 μM. Ginsenoside Rb3 also inhibited the induction of COX-2 and iNOS mRNA. | ||
| M4075 | Ginsenoside-Rd | NF-κB |
| Gypenoside VIII | ||
| Ginsenoside Rd inhibited NF-κB transcriptional activity induced by TNFα with IC50 of 12.05±0.82 μM. Ginsenoside Rd inhibited the expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibited CYP2D6, CYP1A2, CYP3A4 and CYP2C9 with IC50 of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM and 85.1±9.1 μM, respectively. | ||
| M4523 | Specnuezhenide | NF-κB |
| Specnuezhenide ((8E)-Nuezhenide) was separated from the fruit of the ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) inhibited IL-1β -induced chondrocyte inflammation by inhibiting NF-κB and WNT /β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) showed anti-inflammatory effects in rat models of osteoarthritis (OA). | ||
| M4680 | Rubimaillin | NF-κB |
| Mollugin is Rubia Cordifolia L. Is a major bioactive ingredient in the. Mollugin has anticancer effects by inhibiting NF-κB activation induced by TNF-α. Mollugin can enhance the osteogenic effect of BMP-2 through the P38-Smad signaling pathway. | ||
| M22238 | Emetine dihydrochloride hydrate | Autophagy |
| Emetine dihydrochloride hydrate is an alkaloid that has been found in ipecac root and has diverse biological activities. Emetine inhibits NF-κB signaling induced by TNF-α or IL-1β (IC50s = 2 and 4.2 μM, respectively, in a cell-based β-lactamase reporter assay), increases caspase-3/7 activity in ME180 cells (EC50 = 1.1 μM), and is cytotoxic to HeLa cells. | ||
| M27932 | SRTCX1002 | Sirtuin |
| SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively. | ||
| M28589 | SP-100030 | NF-κB |
| SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA). | ||
| M29339 | SB-284851-BT | p38 MAPK |
| SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 µM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 µM) and BRD4 (1)(IC50=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET). | ||
| M38796 | Homobutein | Parasite |
| Homobutein is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation. | ||
| M39015 | Deoxysappanone B | p38 MAPK |
| Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage. | ||
| M39017 | Emodic acid | p38 MAPK |
| Emodic acid (NSC624610) inhibits the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP. | ||
| M40637 | TD-1092 | IAP |
| TD-1092 is a pan-inhibitor of apoptosis (IAP) degrader with two different types of E3 ligase conjugates, IAP and CRBN, that induces proteasomal degradation of cIAP2 and XIAP in a CRBN-dependent manner. TD1092 also activates apoptotic proteases (apoptosis 3/7) and leads to apoptosis by promoting IAP degradation. In addition, TD1092 also blocks the TNFα-mediated NF-κB signaling pathway and inhibits the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can be used as a PROTAC for cancer research. | ||
| M42741 | NF-κB-IN-9 | NF-κB |
| NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). | ||
| M55225 | PTD-p65-P1 Peptide TFA | NF-κB |
| PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis. | ||
| M55381 | Recombinant Human IL-25/IL-17E (HEK293, C-6His) | Cytokines and Growth Factors |
| Interleukin-25; Interleukin-17E | ||
| Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. | ||
| M55382 | Recombinant Human IL-25/IL-17E (E. coli, C-His) | Cytokines and Growth Factors |
| Interleukin-25; Interleukin-17E | ||
| Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. | ||
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