About 21 results found for searched term "K22" (0.09 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M3792 | Vatalanib | VEGFR/PDGFR |
| CGP-7978, PTK 787, ZK222584 | ||
| Vatalanib is an inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. | ||
| M5231 | GSK2269557 | PI3K |
| Nemiralisib; GSK-2269557 | ||
| Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9). | ||
| M6139 | GSK2256098 | FAK |
| GTPL7939 | ||
| GSK2256098 is a potent, selective, reversible, and ATP competitive FAK kinase inhibitor with apparent Ki of 0.4 nM. | ||
| M9148 | SRT2104 | Sirtuin |
| GSK2245840 | ||
| SRT2104 is a first-in-class, selective, blood-brain barrier-crossing SIRT1 activator for use in studies related to diabetes and Huntington's disease. | ||
| M9178 | GSK2292767 | PI3K |
| GSK2292767 is a potent and selective PI3Kδ inhibitor. | ||
| M10824 | GSK2245035 | TLR |
| GSK2245035 is a highly potent, selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential stimulation of interferon type 1 (IFN). GSK2245035 for IFNα and TNFα pEC50 9.3 and 6.5, respectively. GSK2245035 effectively inhibits allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 has the potential for asthma. | ||
| M11467 | GSK-2250665A | Itk |
| GSK2250665; GSK-2250665 | ||
| GSK-2250665A is a Itk inhibitor with pKi value of 9.2. | ||
| M14423 | GSK2256294A | Epoxide Hydrolase |
| GSK 2256294 | ||
| GSK2256294A is a potent, reversible, tight binding inhibitor of isolated recombinant human sEH (soluble epoxide hydrolase) (IC50 = 27 pM; t1/2 = 121 min) and displays potent inhibition against the rat (IC50 = 61 pM) and murine (IC50 = 189 pM) orthologs of sEH. | ||
| M28023 | GSK2239633A | CCR |
| GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96 ± 0.11. | ||
| M28445 | GSK2200150A | Antibiotic |
| GSK2200150A, identified by high-throughput screening (HTS) campaign, is an anti-tuberculosis (TB) agent. | ||
| M28948 | GSK2226649A | Others |
| GSK2226649A (compound 2) is a novel activator of satellite cell proliferation and enhanced repair of damaged muscle. | ||
| M29632 | M4K2234 | ALK |
| M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC50s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer. | ||
| M57754 | K22 | Anti-infection |
| ZIKV inhibitor K22 | ||
| K22 is an inhibitor of coronavirus RNA synthesis that specifically targets membrane-associated coronavirus RNA synthesis. K22 effectively blocks replication of multiple coronaviruses by inhibiting the critical step of viral replication complex anchoring to host cell membranes to form double-membrane vesicles (DMVs). K22 exhibits broad-spectrum antiviral activity against diverse coronaviruses. | ||
| M60119 | PHF5A Human Pre-designed siRNA Set | siRNA |
| PHD finger protein 5A | ||
| Human PHF5A Pre-designed siRNA Set contains three designed siRNAs for PHF5A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control. Gene ID: 84844 | ||
| M60558 | Rspo2 Mouse Pre-designed siRNA Set | siRNA |
| R-spondin 2 | ||
| Mouse Rspo2 Pre-designed siRNA Set contains three designed siRNAs for Rspo2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control. Gene ID: 239405 | ||
| M61433 | TBC1D15 Mouse Pre-designed siRNA Set | siRNA |
| TBC1 domain family, member 15 | ||
| Mouse TBC1D15 Pre-designed siRNA Set contains three designed siRNAs for TBC1D15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control. Gene ID: 66687 | ||
| M63107 | WDR4 Mouse Pre-designed siRNA Set | siRNA |
| WD repeat domain 4 | ||
| Mouse WDR4 Pre-designed siRNA Set contains three designed siRNAs for WDR4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control. Gene ID: 57773 | ||
| M63144 | Arid5a Mouse Pre-designed siRNA Set | siRNA |
| AT-rich interaction domain 5A | ||
| Mouse Arid5a Pre-designed siRNA Set contains three designed siRNAs for Arid5a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control. Gene ID: 214855 | ||
| M63847 | CHCHD2 Human Pre-designed siRNA Set | siRNA |
| coiled-coil-helix-coiled-coil-helix domain containing 2 | ||
| Human CHCHD2 Pre-designed siRNA Set contains three designed siRNAs for CHCHD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control. Gene ID: 51142 | ||
| M64063 | cux2 Mouse Pre-designed siRNA Set | siRNA |
| cut-like homeobox 2 | ||
| Mouse cux2 Pre-designed siRNA Set contains three designed siRNAs for cux2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control. Gene ID: 13048 | ||
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