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Cat. No. M11467
GSK-2250665A Structure

GSK2250665, GSK 2250665, GSK-2250665, GSK2250665A, GSK 2250665A,

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Gsk-2250665a, an Itk inhibitor with pKi = 9.2, shows Itk selectivity against Aurora B kinase and Btk (pIC50 values 6.4 and 6.5, respectively) and a group of other kinases. Inhibit IFNγ production in PBMC.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 459.61
Formula C26H29N5OS
CAS Number 1246030-96-5
Purity >98%
Solubility N/A
Storage at -20°C
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Keywords: GSK-2250665A, GSK2250665, GSK 2250665, GSK-2250665, GSK2250665A, GSK 2250665A, supplier, Enzymes & Coenzymes, inhibitors

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