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Itk Interleukin inducible T-cell kinase


Cat.No.  Name Information
M43518 ITK degrader 2 ITK degrader 2 is a modulator of targeted ubiquitination and a targeted protein degrading molecule.
M43517 ITK degrader 1 ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice).
M28620 PRN694  PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo.
M28596 GNE-9822  GNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma.
M28149 ITK inhibitor 2  ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor, with an IC50 of 2 nM.
M27849 ITK antagonist  ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM.
M11467 GSK-2250665A GSK-2250665A is a Itk inhibitor with pKi value of 9.2.

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