Itk Interleukin inducible T-cell kinase

Inhibitor

Cat.No.	Name	Information
M43518	ITK degrader 2	ITK degrader 2 is a modulator of targeted ubiquitination and a targeted protein degrading molecule.
M43517	ITK degrader 1	ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice).
M28620	PRN694	PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo.
M28596	GNE-9822	GNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma.
M28149	ITK inhibitor 2	ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor, with an IC50 of 2 nM.
M27849	ITK antagonist	ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM.
M11467	GSK-2250665A	GSK-2250665A is a Itk inhibitor with pKi value of 9.2.